Antithrombin inhibition using nanobodies to correct bleeding in hemophilia
نویسندگان
چکیده
منابع مشابه
Bleeding in carriers of hemophilia.
A wide range of factor VIII and IX levels is observed in heterozygous carriers of hemophilia as well as in noncarriers. In female carriers, extreme lyonization may lead to low clotting factor levels. We studied the effect of heterozygous hemophilia carriership on the occurrence of bleeding symptoms. A postal survey was performed among most of the women who were tested for carriership of hemophi...
متن کاملHemophilia A: an ideal disease to correct in utero
Hemophilia A (HA) is the most frequent inheritable defect of the coagulation proteins. The current standard of care for patients with HA is prophylactic factor infusion, which is comprised of regular (2-3 times per week) intravenous infusions of recombinant or plasma-derived FVIII to maintain hemostasis. While this treatment has greatly increased the quality of life and lengthened the life expe...
متن کاملManagement of joint bleeding in hemophilia.
Hemarthrosis, the hallmark of severe hemophilia, is the major cause of serious bleeding events, disability and reduced quality of life in patients with factor VIII or factor IX deficiency. Joint bleeding is one of the greatest challenges confronting individuals treating hemophilia, and its economic impact is enormous. This article reviews the current management of hemophilic joint bleeding and ...
متن کاملAcquired hemophilia: a critical bleeding syndrome.
©2004, Ferrata Storti Foundation A69 year old man attended the emergency department because of severe abdominal pain of acute onset. At physical examination the patient had clinical signs of acute abdomen; he had been on prednisone for twelve months for a polymyalgia syndrome. No cutaneous or mucosal bleeding was evident. The family and personal history was not significant for a bleeding tenden...
متن کاملThe bleeding time is longer than normal in hemophilia.
Bleeding times were performed on 71 hemophiliacs using the Simplate II device. Eight patients receiving Indocin or Motrin for hemophilic arthropathy were evaluated separately from the remaining 63 who had a mean bleeding time of 7.65 +/- 3.20 min (1 SD) compared to the control group of 5.35 +/- 1.49 min (p less than 0.005). No difference was found when 26 mild hemophiliacs who had received less...
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ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2020
ISSN: 1757-4676,1757-4684
DOI: 10.15252/emmm.202012143